Abstract
The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.
MeSH terms
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Amines / chemistry*
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Animals
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Complement Activation / drug effects*
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Ligands
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Membrane Proteins / metabolism*
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Mice
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Mice, Inbred BALB C
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Piperidines / chemical synthesis
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Piperidines / pharmacology*
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Protein Binding
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Protein Serine-Threonine Kinases / metabolism
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Receptors, Complement / metabolism*
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Structure-Activity Relationship
Substances
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Amines
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Ligands
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Membrane Proteins
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Piperidines
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Receptors, Complement
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complement C3a receptor
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Protein Serine-Threonine Kinases